The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-
2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

Endothelin, a recently discovered peptide produced by endothelial cells, contracts vascular
strips in vitro with greater potency than any previously known vasoconstrictor. Infusions of …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Endothelins are ubiquitously produced 21-amino-acid peptides that were discovered as an
endothelial product and may play important roles in cardiovascular physiology and …

Endothelin was isolated and identified in 1988 by Yanagisawa et al. The endothelin family
consists of 21 amino acid isoforms endothelin-1, endothelin-2 and endothelin-3. Endothelin …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

The endothelins are a family of 21–amino acid peptides that are powerful vasoconstrictors.
They may also induce vascular hypertrophy. These peptides may participate through these …

The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many
different tissues, particularly in the endothelium of blood vessels. ET-1 is the main …