The receiver operating characteristic (ROC) curve and their associated summary indices,
such as the Youden index, are statistical tools commonly used to analyze the discrimination …

Abstract The Youden Index is a frequently used summary measure of the ROC (Receiver
Operating Characteristic) curve. It both, measures the effectiveness of a diagnostic marker …

Continuous markers are often used to discriminate between diseased and healthy
populations. In this context, the receiver operating characteristic (ROC) curve is a popular …

The receiver operating characteristic (ROC) curve is used to evaluate a biomarker's ability
for classifying disease status. The Youden Index (J), the maximum potential effectiveness of …

After establishing the utility of a continuous diagnostic marker investigators will typically
address the question of determining a cut-off point which will be used for diagnostic …

In diagnostic studies, the receiver operating characteristic (ROC) curve and the area under
the ROC curve are important tools in assessing the utility of biomarkers in discriminating …

Methods of evaluating and comparing the performance of diagnostic tests are of increasing
importance as new tests are developed and marketed. When a test is based on an observed …

In the field of diagnostic studies, the area under the ROC curve (AUC) serves as an overall
measure of a biomarker/diagnostic test's accuracy. Youden index, defined as the overall …

In order to compare the discriminatory effectiveness of two diagnostic markers the equality of
the areas under the respective Receiver Operating Characteristic Curves is commonly …

Costs can hamper the evaluation of the effectiveness of new biomarkers. Analysis of smaller
numbers of pooled specimens has been shown to be a useful cost-cutting technique. The …