Signals from the microenvironment around a cell are known to influence cell behavior.
Material properties, such as biochemical composition and substrate stiffness, are today …

Adherent cells residing within tissues or biomaterials are presented with 3D geometrical
cues from their environment, often in the form of local surface curvatures. While there is …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

Topography-driven alterations in cell morphology tremendously influence cell biological
processes, particularly stem cell differentiation. Aligned topography is known to alter the cell …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

The intrinsic architecture of biological tissues and of implanted biomaterials provides cells
with large-scale geometrical cues. To understand how cells are able to sense and respond …

The physiological microenvironment of the stem cell niche, including the three factors of
stiffness, topography, and dimension, is crucial to stem cell proliferation and differentiation …

Surface topography impacts on cell growth and differentiation, but it is not trivial to generate
defined surface structures and to assess the relevance of specific topographic parameters …

Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …

Cell migration is a fundamental process that is crucial for many biological functions in the
body such as immune responses and tissue regeneration. Dysregulation of this process is …