Nowadays, patients with a solid organ transplant or a vascularized composite allotransplant
(VCA) transplant rely on life-long immunosuppression or a highly controversial bone marrow …

Background Targeting the process of central (thymic) selection of developing T lymphocytes
is the key mechanism for transplant tolerance induction mediated bybone marrow …

Vascularized composite allotransplantation (VCA) refers to the utilization of multiple types of
tissue as a single functional transplantation unit for the management severe injury and …

Background. In this study, we evaluated the role of host thymus in tolerance induction in
composite tissue allografts (CTA) across major histocompatibility complex (MHC) barrier …

While allogeneic bone marrow transplantation (BMT) has long been known to be capable of
inducing donor-specific tolerance and hence permitting allograft acceptance without …

Background. Although bone marrow transplantation (BMT) has become a valuable strategy
for the treatment of various intractable diseases in recent years, success rates remain low in …

Peripheral tolerance can be achieved in many but not all murine allograft models. The
requirements for controlling more aggressive immune responsiveness and generating …

Thymus transplantation enables recipient T cells to develop and mature within the donor
thymus and achieve donor-specific transplantation tolerance. The relationship between the …

Bone marrow transplantation (BMT) is a widely used therapy for blood cancers and primary
immunodeficiency. Following transplant, the thymus plays a key role in immune …

Discussion still continues regarding whether self‐tolerance is imparted within the thymus by
the thymic epithelial cells (TEC) or by the bone marrow‐derived (BMD) dendritic cells and …