Targeting of the CD45RB isoform by mAb (anti-CD45RB) effectively induces donor-specific
tolerance to allografts. The immunological mechanisms underlying the tolerant state remain …

Despite extensive research, our understanding of immunological tolerance to self-antigens
is incomplete, and the goal of achieving tolerance to allogeneic transplanted tissue remains …

Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in
recipients of allogeneic bone marrow transplants through yet to be defined mechanisms …

Three months after mixed thymie graft transplantation, skin grafting was performed and the
reconstilution of CD4+ CD25+ T cell subsets in the recipients was detected by flow …

The identification and therapeutic potential of T cells that intrinsically suppress immune
responses, defined by the expression of FoxP3 and referred to as regulatory T (Treg) cells, 1 …

Compelling experimental evidence confirms that the robustness and longevity of mixed
chimerism (MC) relies on the persistence and availability of donor-derived hematopoietic …

Purpose We have achieved tolerance of cardiac allografts in cynomolgus monkeys for the
first time by using a mixed chimerism-based conditioning protocol and by co-transplanting a …

In this study, we showed that aly/aly mice, which are devoid of lymph nodes and Peyer's
patches, acutely rejected fully allogeneic skin and heart grafts. They mounted potent …

Introduction: Neonatal tolerance promotes specific long-term acceptance to skin allografts. It
is believed that this tolerant state is induced and maintained by the establishment of semi …

Anti-donor T cells mediate graft rejection and the frequency of anti-donor T cells directly
correlates with transplant outcome. It has long been noted that long-term tolerance was …