Methods: Ltx were performed using a non-arterialized cuff technique. For the adoptive
transfer experiments, TCR-tg cells (4C (CD4-direct), TEA (CD4-indirect), and 2C (CD8 …

The strategy to achieve acquired central immunological tolerance by injection of foreign
antigens into the thymus was popularized in the early 1990s. It was first demonstrated by …

We developed a mouse model of heterotopic limb transplantation in which we took
advantage of Thy1. 1 and Thy1. 2 congenic strains to track and characterize donor T cells, to …

Organ transplantation is an effective way to treat many end-stage diseases. In order to
overcome post-transplant rejection, immunosuppressive agents have been widely used, but …

Grafts of thymic epithelium (TE) rudiments restore T cell development and function in
allogeneic athymic mice. These TE chimeras are specifically tolerant to grafts of peripheral …

Background. We have tested whether fetal porcine thymic tissue transplantation can lead to
tolerance across a discordant (pig-to-baboon) xenogeneic barrier. Methods. Six baboons …

Exploration of novel strategies in organ transplantation to prolong allograft survival and
minimizing the need for long-term maintenance immunosuppression must be pursued …

Background: Tolerance induction through mixed chimerism holds promise for clinical
translation but has only been investigated in young recipients so far. Frequencies of memory …

ADULT VASCULARIZED THYMUS TRANSPLANTATION RESTORES HOST IMMU... :
Transplantation ADULT VASCULARIZED THYMUS TRANSPLANTATION RESTORES …