The effects of growth hormone on adipose tissue: old observations, new mechanisms

JJ Kopchick, DE Berryman, V Puri, KY Lee… - Nature Reviews …, 2020 - nature.com
The ability of growth hormone (GH) to induce adipose tissue lipolysis has been known for
over five decades; however, the molecular mechanisms that mediate this effect and the …

Growth hormone and adipose tissue: beyond the adipocyte

DE Berryman, EO List, L Sackmann-Sala… - Growth Hormone & IGF …, 2011 - Elsevier
The last two decades have seen resurgence in research focused on adipose tissue. In part,
the enhanced interest stems from an alarming increase in obesity rates worldwide. However …

Effect of growth hormone on insulin signaling

R Sharma, JJ Kopchick, V Puri, VM Sharma - Molecular and cellular …, 2020 - Elsevier
Growth hormone (GH) is a pleiotropic hormone that coordinates an array of physiological
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …

Action of growth hormone in adipose tissue

B Richelsen - Hormones, 1997 - karger.com
Growth hormone (GH) has diverse and still not fully elucidated effects on adipose tissue.
Both preadipocytes and mature adipocytes possess specific GH receptors. GH may mediate …

Growth hormone's effect on adipose tissue: quality versus quantity

DE Berryman, EO List - International Journal of Molecular Sciences, 2017 - mdpi.com
Obesity is an excessive accumulation or expansion of adipose tissue (AT) due to an
increase in either the size and/or number of its characteristic cell type, the adipocyte. As one …

The intricate role of growth hormone in metabolism

A Vijayakumar, S Yakar, D LeRoith - Frontiers in endocrinology, 2011 - frontiersin.org
Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate
and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 …

Growth hormone and adipocyte function in obesity

SY Nam, C Marcus - Hormone research, 2000 - karger.com
In obesity, growth hormone (GH) secretion is impaired which is considered a consequence
rather than a cause of obesity. GH regulates the expression of GH receptor and the …

The metabolic effects of growth hormone in adipose tissue

VE Chaves, FM Júnior, GL Bertolini - Endocrine, 2013 - Springer
There is a general consensus that a reduction in growth hormone (GH) secretion results in
obesity. However, the pathophysiologic role of GH in the metabolism of lipids is yet to be …

Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues

S Lall, LYC Tung, C Ohlsson, JO Jansson… - Biochemical and …, 2001 - Elsevier
Growth hormone secretagogues (GHSs) stimulate growth hormone (GH) secretion, which is
lipolytic. Here we compared the effects of twice daily sc treatment of GH and the GHS …

Biological effects of growth hormone on carbohydrate and lipid metabolism

A Vijayakumar, R Novosyadlyy, YJ Wu, S Yakar… - Growth Hormone & IGF …, 2010 - Elsevier
This review will summarize the metabolic effects of growth hormone (GH) on the adipose
tissue, liver, and skeletal muscle with focus on lipid and carbohydrate metabolism. The …