Purpose: To assess the potential of delivering nerve growth factor (NGF) to the brain along
the olfactory neural pathway for the treatment of Alzheimer's disease. Methods …

Nerve growth factor (NGF) delivery to the brain of patients appears to be an emerging
potential therapeutic approach to neurodegenerative disease, such as Alzheimer's disease …

Nerve growth factor (NGF) has a great potential for the treatment of Alzheimer's disease.
However, the therapeutic administration of NGF represents a significant challenge, due to …

The main objective of the study was to investigate the efficacy of chitosan to facilitate brain
bioavailability of intranasally administered nerve growth factor (NGF). In vitro permeability …

Olfactory ensheathing cells (OECs) are a unique type of macroglia with axonal growth‐
promoting properties. The migrating ability of OECs in CNS is essential for neural …

Nerve growth factor (NGF) has been proved with the potential of promoting neurogenesis in
adult mammalians. This study was aimed to investigate the effect of intranasal (IN) NGF on …

Nerve growth factor (NGF) and its receptor (NGFR) are proteins that have a role in the
normal development and survival of neurons in the peripheral and central nervous systems …

In the primary olfactory pathway axons of olfactory neurons (ONs) are accompanied by
ensheathing cells (ECs) as the fibres course towards the olfactory bulb. Ensheathing cells …

Phenotypic knockout of nerve growth factor (NGF) activity in transgenic anti-NGF mice
(AD11 mice) results in a progressive neurodegenerative phenotype resembling Alzheimer's …

Nerve growth factor (NGF), a classic neurotropic factor, promotes neuronal survival,
maintenance, regeneration and differentiation in the peripheral nervous system and parts of …