The ABC of major histocompatibility complexes and T cell receptors in health and disease
K Kedzierska, M Koutsakos - Viral Immunology, 2020 - liebertpub.com
A seminal discovery of major histocompatibility complex (MHC) restriction in T cell
recognition by Peter Doherty and Rolf Zinkernagel has led to 45 years of exciting research …
recognition by Peter Doherty and Rolf Zinkernagel has led to 45 years of exciting research …
TCR repertoire evolution during maintenance of CMV‐specific T‐cell populations
K Schober, VR Buchholz, DH Busch - Immunological reviews, 2018 - Wiley Online Library
During infections and cancer, the composition of the T‐cell receptor (TCR) repertoire of
antigen‐specific CD 8+ T cells changes over time. TCR avidity is thought to be a major driver …
antigen‐specific CD 8+ T cells changes over time. TCR avidity is thought to be a major driver …
Impact of epitope density on CD8+ T cell development and function
GL Cosma, LC Eisenlohr - Molecular immunology, 2019 - Elsevier
Effective immune responses against intracellular pathogens and tumors frequently rely upon
CD8+ cytotoxic T lymphocytes (CTLs). In turn, CTL detection of foreign material from viruses …
CD8+ cytotoxic T lymphocytes (CTLs). In turn, CTL detection of foreign material from viruses …
Clonotype‐specific avidity influences the dynamics and hierarchy of virus‐specific regulatory and effector CD4+ T‐cell responses
J Liu, S Cao, G Peppers, SH Kim… - European Journal of …, 2014 - Wiley Online Library
A key component of immunity against viruses, CD4+ T cells expand and differentiate into
functional subsets upon primary infection, where effector (Teff) cells facilitate infection …
functional subsets upon primary infection, where effector (Teff) cells facilitate infection …
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity
Antigen-specific T cell receptors (TCRs) recognise complexes of immunogenic peptides (p)
and major histocompatibility complex (MHC) glycoproteins. Responding T cell populations …
and major histocompatibility complex (MHC) glycoproteins. Responding T cell populations …
αβ T cell receptors as predictors of health and disease
The diversity of antigen receptors and the specificity it underlies are the hallmarks of the
cellular arm of the adaptive immune system. T and B lymphocytes are indeed truly unique in …
cellular arm of the adaptive immune system. T and B lymphocytes are indeed truly unique in …
T-cell virtuosity in ''knowing thyself”
O Acuto - Frontiers in Immunology, 2024 - frontiersin.org
Major Histocompatibility Complex (MHC) I and II and the αβ T-cell antigen receptor (TCRαβ)
govern fundamental traits of adaptive immunity. They form a membrane-borne ligand …
govern fundamental traits of adaptive immunity. They form a membrane-borne ligand …
Structural and biophysical determinants of αβ T‐cell antigen recognition
The molecular rules that govern MHC restriction, and allow T‐cells to differentiate between
peptides derived from healthy cells and those from diseased cells, remain poorly …
peptides derived from healthy cells and those from diseased cells, remain poorly …
The great balancing act: regulation and fate of antiviral T‐cell interactions
EA Moseman, DB McGavern - Immunological reviews, 2013 - Wiley Online Library
The fate of T lymphocytes revolves around a continuous stream of interactions between the
T‐cell receptor (TCR) and peptide‐major histocompatibility complex (MHC) molecules …
T‐cell receptor (TCR) and peptide‐major histocompatibility complex (MHC) molecules …
Attenuated T cell responses to a high-potency ligand in vivo
E Corse, RA Gottschalk, M Krogsgaard, JP Allison - PLoS biology, 2010 - journals.plos.org
αβ T cell receptor (TCR) recognition of foreign peptides bound to major histocompatibility
complex (pMHC) molecules on the surface of antigen presenting cells is a key event in the …
complex (pMHC) molecules on the surface of antigen presenting cells is a key event in the …