Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

S Bhattacharya, L Mondal, B Mukherjee, L Dutta… - … , Biology and Medicine, 2018 - Elsevier
Hepatocellular carcinoma (HCC) is one of the major causes of cancer related death globally.
Apigenin, a dietary flavonoid, possesses anti-tumor activity against HCC cells in-vitro …

[HTML][HTML] The effect of encapsulated apigenin nanoparticles on HePG-2 cells through regulation of P53

MM Mabrouk Zayed, HA Sahyon, NAN Hanafy… - Pharmaceutics, 2022 - mdpi.com
Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer
activity. This study was designed, for the first time, to load Ap into chitosan to improve its …

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells

LC Chiang, LT Ng, IC Lin, PL Kuo, CC Lin - Cancer letters, 2006 - Elsevier
Apigenin, a common dietary flavonoid abundantly present in fruits and vegetables, is
believed to possess preventive and therapeutic potential against cancers. In this study, the …

Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns

J Cai, XL Zhao, AW Liu, H Nian, SH Zhang - Phytomedicine, 2011 - Elsevier
Apigenin, a common plant flavonoid, has been shown to possess anti-tumor properties;
however, the underlying molecular mechanisms are still not completely understood. In the …

[HTML][HTML] Apigenin inhibits the growth of hepatocellular carcinoma cells by affecting the expression of microRNA transcriptome

SM Wang, PW Yang, XJ Feng, YW Zhu, FJ Qiu… - Frontiers in …, 2021 - frontiersin.org
Background Apigenin, as a natural flavonoid, has low intrinsic toxicity and has potential
pharmacological effects against hepatocellular carcinoma (HCC). However, the molecular …

Apigenin-loaded galactose tailored PLGA nanoparticles: A possible strategy for liver targeting to treat hepatocellular carcinoma

S Ganguly, S Dewanjee, R Sen… - Colloids and Surfaces B …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is the most common hepatic malignancy worldwide.
Recent reports focusing on the efficacy of apigenin-loaded nanoparticles (NPs) in combating …

[HTML][HTML] Apigenin as tumor suppressor in cancers: Biotherapeutic activity, nanodelivery, and mechanisms with emphasis on pancreatic cancer

M Ashrafizadeh, MR Bakhoda, Z Bahmanpour… - Frontiers in …, 2020 - frontiersin.org
Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its
propensity for early local and distant spread, affected patients possess extremely poor …

[HTML][HTML] Using green biosynthesized kaempferol-coated sliver nanoparticles to inhibit cancer cells growth: An in vitro study using hepatocellular carcinoma (HepG2)

NM Alyami, HM Alyami, R Almeer - Cancer Nanotechnology, 2022 - Springer
The ongoing loss of human life owing to various forms of cancer necessitates the
development of a more effective/honorable therapeutic approach. Moreover, finding a novel …

Selective toxicity of apigenin on cancerous hepatocytes by directly targeting their mitochondria

E Seydi, HR Rasekh, A Salimi… - Anti-Cancer Agents …, 2016 - ingentaconnect.com
Background: hepatocellular carcinoma (HCC) is the third cause of mortality due to cancer
throughout the world. Objective: The main goal of the current research was to evaluate the …

Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent

Y Zhou, Y Yu, H Lv, H Zhang, T Liang, G Zhou… - Food and Chemical …, 2022 - Elsevier
Apigenin (APG) is a flavonoid presence in beverages, vegetables, and fruits containing anti-
diabetic, anti-oxidant, and anti-viral activities, as well as cancer management properties …