Pain and inflammation are inherently linked responses to injury, infection, or chronic
diseases. Given that acute inflammation in humans or mice enhances the analgesic …

Current therapy for inflammatory pain includes the peripheral application of opioid receptor
agonists. Activation of opioid receptors modulates voltage-gated ion channels, but it is …

Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons
project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses …

The peripheral terminals of primary nociceptive neurons play an essential role in pain
detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and …

Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological forms
of pain, and multiple signaling cascades are known to enhance TRPV1 activity under …

Although TRPV1 channels represent a key player of noxious heat sensation, the precise
mechanisms for thermal hyperalgesia remain unknown. We report here that conditional …

Background The vanilloid receptor 1 (TRPV1) is critical in the development of inflammatory
hyperalgesia. Several receptors including G-protein coupled prostaglandin receptors have …

Humans have used opioids to suppress moderate to severe pain for thousands of years.
However, the long-term use of opioids has several adverse effects, such as opioid tolerance …

Opioids are powerful analgesics, but also carry significant side effects and abuse potential.
Here we describe a modulator of the μ-opioid receptor (MOR1), the transient receptor …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel
activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory …