The CCAAT-binding heme activator protein (HAP) complex, comprising the DNA-binding
heterotrimeric complex Hap2/3/5 and transcriptional activation subunit HapX, is a key …

The fungus Cryptococcus neoformans can undergo a-α bisexual and unisexual
reproduction. Completion of both sexual reproduction modes requires similar cellular …

Cryptococcus neoformans is a global fungal pathogen that primarily impacts
immunocompromised individuals. Responsible for~ 200,000 yearly cases in the HIV+ …

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic
transition from a unicellular yeast to multicellular hyphae during opposite sex (mating) and …

Cell type specification is a fundamental process that all cells must carry out to ensure
appropriate behaviors in response to environmental stimuli. In fungi, cell identity is critical for …

The fundamental mechanisms that control eukaryotic development include extensive
regulation at the level of transcription. Gene regulatory networks, composed of transcription …

Sex is orchestrated by the mating-type locus (MAT) in fungi and by sex chromosomes in
plants and animals. In fungi, two patterns of sexuality occur: bipolar with a single, typically …

Cryptococcus neoformans is a pathogenic fungus with a defined sexual cycle involving
haploid MAT α and MAT a cells. Interestingly, MAT α strains are more common, are more …

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic
transition from a unicellular yeast to multicellular hyphae during opposite sex (mating) and …

Sexual reproduction in fungal pathogens such as Cryptococcus provides natural selection
and adaptation of the organisms to environmental conditions by allowing beneficial …