Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: an implication for causal link
Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk
through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain …
through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain …
Accelerated cerebral vascular injury in diabetes is associated with vascular smooth muscle cell dysfunction
Individuals with diabetes are more susceptible to cerebral vascular aging. However, the
underlying mechanisms are not well elucidated. The present study examined whether the …
underlying mechanisms are not well elucidated. The present study examined whether the …
Blood-brain barrier disruption induced cognitive impairment is associated with increase of inflammatory cytokine
Patients with diabetes suffer the higher risk of dementia and the underlying pathological
mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we …
mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we …
Pressure‐independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto‐Kakizaki rat in response to glycaemic control
A Kelly‐Cobbs, MM Elgebaly, W Li, A Ergul - Acta physiologica, 2011 - Wiley Online Library
Aim: We have shown hypertrophic cerebrovascular remodelling in the Goto‐Kakizaki (GK)
rat model of diabetes. This study tested the hypotheses that (1) vascular remodelling …
rat model of diabetes. This study tested the hypotheses that (1) vascular remodelling …
Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models
S Rom, V Zuluaga-Ramirez, S Gajghate, A Seliga… - Molecular …, 2019 - Springer
End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …
Diabetes mellitus impairs cognitive function in middle-aged rats and neurological recovery in middle-aged rats after stroke
Background and Purpose—Diabetes mellitus (DM) is a common metabolic disease among
the middle-aged and older population, which leads to an increase of stroke incidence and …
the middle-aged and older population, which leads to an increase of stroke incidence and …
Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction
Y Liu, H Zhang, S Wang, Y Guo… - American Journal …, 2021 - journals.physiology.org
Diabetes mellitus (DM) is one of the primary pathological factors that contributes to aging-
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …
[HTML][HTML] Aging diabetes, deconstructing the cerebrovascular wall
Fan Fan, George W. Booz, Richard J. Roman www. aging-us. com AGING 2021, Vol. 13, No.
7 www. aging-us. com 9158 AGING models [3]. Impairments in CBF autoregulation …
7 www. aging-us. com 9158 AGING models [3]. Impairments in CBF autoregulation …
Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: implication of cilostazol for diabetes mellitus-induced …
KJ Kwon, EJ Lee, MK Kim, SY Kim, JN Kim… - Neurobiology of …, 2015 - Elsevier
Many patients with diabetes are at increased risk of cognitive dysfunction and dementia.
Diabetes mellitus is a vascular risk factor that may increase the risk of dementia through its …
Diabetes mellitus is a vascular risk factor that may increase the risk of dementia through its …