Urine output is widely used as a criterion for the diagnosis of AKI. Although several potential
mechanisms of septic AKI have been identified, regulation of urine flow after glomerular …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Background Complement activation plays an important role in the pathogenesis of renal
ischemia-reperfusion (IR) injury (IRI), but whether this involves damage to the …

Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an
effector responsible for apoptosis execution, is activated within the peritubular capillary …

Objectives: We developed quantitative methods to analyze microbubble kinetics based on
renal contrast-enhanced ultrasound imaging combined with measurements of sublingual …

Elevated venous pressure can be associated with severe tissue injury. Few links, however,
between venous hypertension and tissue damage have been established. We examined …

Aim: To study whether microvascular leukocyte accumulation after rat renal ischemia and
reperfusion (IR) is decreased by Rho kinase inhibition, independently of effects upon nitric …

Bilateral renal artery occlusion (RAO) for 120 minutes in dogs results in acute tubular
necrosis (ATN) and peritubular capillary (PTC) congestion with rapidly deteriorating renal …

The role of renal microvascular endothelial cell injury in the pathophysiology of ischemic
acute renal failure (ARF) remains largely unknown. No consistent morphological alterations …

Background In the past years evidence has been growing about the interconnection of
chronic kidney disease and acute kidney injury. The underlying pathophysiological …