Sepsis and endotoxemia induce defects in renal tubule function, but the mechanisms are
poorly understood. Recently, we demonstrated that lipopolysaccharide (LPS) inhibits …

Although heparin is better known as an anticoagulant, it also has several anti-inflammatory
effects. Heparin is known to inhibit neutrophil adhesion, chemotaxis and oxygen free radical …

Background. Although neutrophils and T cells are important in mediating renal injury
following ischaemia/reperfusion, the role of macrophages is still unknown. Using liposomal …

Objective: Sparse data are available on renal consequences of hemorrhagic shock in mice.
This study aimed to extend the current knowledge on functional and morphologic renal …

Tetracyclines exhibit significant anti-inflammatory properties, inhibit matrix
metalloproteinases (MMPs), and are protective in models of ischemia-reperfusion injury …

Objective Spinal cord injury induced by ischemia/reperfusion is a devastating complication
of aortic repair. Despite developments for prevention and treatment of spinal cord injury …

Increased pressure due to postischemic edema aggravates renal ischemia-reperfusion
injury (IRI). Prophylactic surgical decompression using microcapsulotomy improves kidney …

Background The incidence of acute kidney injury following severe sepsis is higher in the
elderly. We hypothesized that microvascular endothelium is" primed" by aging and that …

Acute kidney injury is a frequent and serious complication of sepsis. To better understand
the development of sepsis-induced acute kidney injury, we performed the first time …

Renal ischemia-reperfusion injury (IRI) is a severe complication of major surgery and a risk
factor for increased morbidity and mortality. Here, we investigated mechanisms that might …