The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis

MM Bian, YM Xu, L Zhang, HZ Yan, JX Gao… - The Journal of Spinal …, 2024 - Taylor & Francis
Background Oxidative stress is a crucial factor contributing to the occurrence and
development of secondary damage in spinal cord injuries (SCI), ultimately impacting the …

Neuroprotective effects of alpha-lipoic acid in experimental spinal cord injury in rats

HZ Toklu, T Hakan, H Celik, N Biber… - The journal of spinal …, 2010 - Taylor & Francis
Background: Oxidative stress is a mediator of secondary injury to the spinal cord following
trauma. Objective: To investigate the putative neuroprotective effect of α-lipoic acid (LA), a …

The effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in rats

M Yucel, OY Aktas, O Zengi, A Tas, A Tufan, B Eren… - 2023 - annalsmedres.org
Aim: Crush injury damages the nerve, affects its function and causes oxidative stress. Alpha-
lipoic acid (ALA) is an antioxidant agent with protective effects on the nerve tissue. In this …

The dose-dependent neuroprotective effect of alpha-lipoic acid in experimental spinal cord injury

M Sayin, P Temiz, A Var… - Neurologia i neurochirurgia …, 2013 - journals.viamedica.pl
Background and purpose Free radical production after spinal cord injury (SCI) plays an
important role in secondary damage. The aim of this study was to investigate …

Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: assessed with functional, molecular and electromicroscopic analyses

R Demir, M Yayla, E Akpinar, M Cakir… - International Journal …, 2014 - Taylor & Francis
Aim: The present study aimed to demonstrate protective effects of alpha lipoic acid on
experimental sciatic nerve crush injury model assessed with functional and …

[HTML][HTML] Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve

M Senoglu, V Nacitarhan, EB Kurutas… - Journal of brachial …, 2009 - thieme-connect.com
Objective Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is
a neuroprotective metabolic antioxidant. This study was designed to investigate the …

Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat

VR King, WL Huang, SC Dyall, OE Curran… - Journal of …, 2006 - Soc Neuroscience
Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory
treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) …

Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia–reperfusion injury in rabbits

H Emmez, Z Yildirim, A Kale, M Tönge, E Durdağ… - Acta …, 2010 - Springer
Purpose Radical oxygen species produced after injury counteracts antioxidant activity and
frequently causes severe oxidative stress for the tissues. Alpha-lipoic acid is a powerful …

[HTML][HTML] α-Lipoic acid promotes neurological recovery after ischemic stroke by activating the Nrf2/HO-1 pathway to attenuate oxidative damage

C Lv, S Maharjan, Q Wang, Y Sun, X Han… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Alpha-lipoic acid (α-LA) has been demonstrated to be protective against
cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying …

Anti-oxidative effect of lipoic acid in spinal cord ischemia/reperfusion

S Shaafi, MR Afrooz, B Hajipour, A Dadashi… - Medical Principles and …, 2010 - karger.com
Objective: Lipoic acid (LA) is an effective anti-oxidant agent that can scavenge free radicals
in biological systems. The aim of this research was to study the probable protective effect of …