The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis
MM Bian, YM Xu, L Zhang, HZ Yan, JX Gao… - The Journal of Spinal …, 2024 - Taylor & Francis
Background Oxidative stress is a crucial factor contributing to the occurrence and
development of secondary damage in spinal cord injuries (SCI), ultimately impacting the …
development of secondary damage in spinal cord injuries (SCI), ultimately impacting the …
Neuroprotective effects of alpha-lipoic acid in experimental spinal cord injury in rats
Background: Oxidative stress is a mediator of secondary injury to the spinal cord following
trauma. Objective: To investigate the putative neuroprotective effect of α-lipoic acid (LA), a …
trauma. Objective: To investigate the putative neuroprotective effect of α-lipoic acid (LA), a …
The effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in rats
Aim: Crush injury damages the nerve, affects its function and causes oxidative stress. Alpha-
lipoic acid (ALA) is an antioxidant agent with protective effects on the nerve tissue. In this …
lipoic acid (ALA) is an antioxidant agent with protective effects on the nerve tissue. In this …
The dose-dependent neuroprotective effect of alpha-lipoic acid in experimental spinal cord injury
M Sayin, P Temiz, A Var… - Neurologia i neurochirurgia …, 2013 - journals.viamedica.pl
Background and purpose Free radical production after spinal cord injury (SCI) plays an
important role in secondary damage. The aim of this study was to investigate …
important role in secondary damage. The aim of this study was to investigate …
Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: assessed with functional, molecular and electromicroscopic analyses
Aim: The present study aimed to demonstrate protective effects of alpha lipoic acid on
experimental sciatic nerve crush injury model assessed with functional and …
experimental sciatic nerve crush injury model assessed with functional and …
[HTML][HTML] Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve
M Senoglu, V Nacitarhan, EB Kurutas… - Journal of brachial …, 2009 - thieme-connect.com
Objective Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is
a neuroprotective metabolic antioxidant. This study was designed to investigate the …
a neuroprotective metabolic antioxidant. This study was designed to investigate the …
Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat
VR King, WL Huang, SC Dyall, OE Curran… - Journal of …, 2006 - Soc Neuroscience
Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory
treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) …
treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) …
Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia–reperfusion injury in rabbits
Purpose Radical oxygen species produced after injury counteracts antioxidant activity and
frequently causes severe oxidative stress for the tissues. Alpha-lipoic acid is a powerful …
frequently causes severe oxidative stress for the tissues. Alpha-lipoic acid is a powerful …
[HTML][HTML] α-Lipoic acid promotes neurological recovery after ischemic stroke by activating the Nrf2/HO-1 pathway to attenuate oxidative damage
C Lv, S Maharjan, Q Wang, Y Sun, X Han… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Alpha-lipoic acid (α-LA) has been demonstrated to be protective against
cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying …
cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying …
Anti-oxidative effect of lipoic acid in spinal cord ischemia/reperfusion
Objective: Lipoic acid (LA) is an effective anti-oxidant agent that can scavenge free radicals
in biological systems. The aim of this research was to study the probable protective effect of …
in biological systems. The aim of this research was to study the probable protective effect of …