Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …

Objective The aim of this work was to characterize the genome-wide DNA methylation profile
of cartilage from three regions of tibial plateau isolated from patients with primary knee …

Osteoporosis is a disease that impacts the elderly. Low estrogen is related to changes in
DNA methylation and consequent alterations in gene expression, leading to a new direction …

DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …

Background The study aimed to analyze aberrantly methylated genes, relevant pathways
and transcription factors (TFs) in osteosarcoma (OS) development. Methods Based on the …

Idiopathic osteoarthritis (OA) is a complex, late-onset disease whose causes are still
unknown. In spite of tremendous efforts, the search for the genes pre-disposing towards …

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

Altered DNA methylation upon ageing may result in many age‐related diseases such as
osteoporosis. However, the changes in DNA methylation that occur in cortical bones, the …

The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being
obesity, age, environmental variables, and genetic predisposition. The available evidence …

Background Osteoporotic vertebral compression fractures (OVCF) in the elderly increase
refracture risk post-surgery, leading to higher mortality rates. Genome-wide association …