Prenatal opioid exposure reprograms the behavioural response to future alcohol reward

GG Grecco, DL Haggerty, KC Reeves, Y Gao… - Addiction …, 2022 - Wiley Online Library
As the opioid crisis has continued to grow, so has the number of infants exposed to opioids
during the prenatal period. A growing concern is that prenatal exposure to opioids may …

Prenatal opioid exposure and vulnerability to future substance use disorders in offspring

Y Abu, S Roy - Experimental neurology, 2021 - Elsevier
The heightened incidence of opioid use during pregnancy has resulted in unprecedented
rates of neonates prenatally exposed to opioids. Prenatal opioid exposure (POE) results in …

Brief Prenatal Ethanol Exposure Alters Behavioral Sensitivity to the Kappa Opioid Receptor Agonist (U 62,066 E) and Antagonist (Nor‐BNI) and Reduces Kappa …

ME Nizhnikov, RM Pautassi, JM Carter… - Alcoholism: Clinical …, 2014 - Wiley Online Library
Background Approximately 10 to 15% of women consume alcohol (ethanol [EtOH]) during
pregnancy in the United States. Even low amounts of EtOH consumption during pregnancy …

Endogenous opioids as substrates for ethanol intake in the neonatal rat: The impact of prenatal ethanol exposure on the opioid family in the early postnatal period

K Bordner, T Deak - Physiology & behavior, 2015 - Elsevier
Background Despite considerable knowledge that prenatal ethanol exposure can lead to
devastating effects on the developing fetus, alcohol consumption by pregnant women …

Limited bedding and nesting increases ethanol drinking in female rats

BJ Parks, P Salazar, L Morrison, MK McGraw… - Pharmacology …, 2024 - Elsevier
Prenatal opioid exposure (POE) and postnatal adverse experiences are early life adversities
(ELA) that often co-occur and increase problematic alcohol (EtOH) drinking during …

[HTML][HTML] The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake

L Granholm, A Todkar, S Bergman, K Nilsson… - Brain research, 2017 - Elsevier
The young brain is highly sensitive to environmental influences that can cause long-term
changes in neuronal function, possibly through altered gene expression. The endogenous …

Mid-to late gestational morphine exposure does not alter the rewarding properties of morphine in adult male rats

MA Riley, I Vathy - Neuropharmacology, 2006 - Elsevier
Prenatal exposure to drugs of abuse often leads to physiological and neurobiological
abnormalities including decreased brain and body weight, cognitive deficits and behavioral …

Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development

SC Simmons, GG Grecco, BK Atwood, FS Nugent - Neuropharmacology, 2023 - Elsevier
In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

Prenatal morphine exposure differentially alters addictive and emotional behavior in adolescent and adult rats in a sex-specific manner

Y Chen, M Du, N Kang, X Guan, B Liang, Z Chen… - Neurochemical …, 2022 - Springer
The effects of prenatal opioid exposure in adult animals has been widely studied, but little is
known about the effects of prenatal opioid on adolescents. Most of the risk behaviors …

Prenatal ethanol exposure increases risk of psychostimulant addiction

R Wang, YL Shen, KA Hausknecht, L Chang… - Behavioural brain …, 2019 - Elsevier
Prenatal ethanol exposure (PE) causes many cognitive and behavioral deficits including
increased drug addiction risk, demonstrated by enhanced ethanol intake and behavioral …