In the renal medullary thick ascending limb (MTAL), inhibiting the basolateral NHE1 Na+/H+
exchanger with amiloride or nerve growth factor (NGF) results secondarily in inhibition of the …

In the medullary thick ascending limb (MTAL) of rat kidney, inhibiting basolateral Na+/H+
exchange with either amiloride or nerve growth factor (NGF) results secondarily in inhibition …

The regulation of epithelial Na+/H+ exchangers (NHEs) by hyposmolality is poorly
understood. In the renal medullary thick ascending limb (MTAL), transepithelial bicarbonate …

Nerve growth factor (NGF) inhibits transepithelial HCO 3− absorption in the rat medullary
thick ascending limb (MTAL). To investigate the mechanism of this inhibition, MTALs were …

A high sodium intake increases the capacity of the medullary thick ascending limb (MTAL) to
absorb HCO3−. Here, we examined the role of the apical NHE3 and basolateral NHE1 …

The signal transduction mechanisms that mediate osmotic regulation of Na+/H+ exchange
are not understood. Recently we demonstrated that hyposmolality increases HCO3 …

Sepsis and endotoxemia induce defects in renal tubule function, but the mechanisms are
poorly understood. Recently, we demonstrated that lipopolysaccharide (LPS) inhibits …

The H+ and HCO3-transporters present in the medullary thick ascending limb (MTAL) of the
kidney are involved in several functions, such as transepithelial transport, defense of cell pH …

The relevance of nongenomic pathways to regulation of epithelial function by aldosterone is
poorly understood. Recently, we demonstrated that aldosterone inhibits transepithelial …

Expression of rat thick limb Na/H exchangers in potassium depletion and chronic metabolic
acidosis. Background Regulation of renal transporter expression has been shown to support …