Inflammatory response and cell death in hepatocytes are hallmarks of chronic liver disease,
and, therefore, can be effective therapeutic targets. Neurotropin®(NTP) is a drug widely …

Background Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its
clinical use is challenged by various types of injuries, including hepatotoxic side effects …

Emergence of analgesic tolerance and dependence to morphine is frequently the limiting
factor in the use of this agent in the management of pain. Hence, this study aimed to …

Naloxone is a non-selective opiate receptor antagonist that is mainly used in the
management of acute opioid overdose or intoxication. Previously, naloxone has been …

Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need
analgesic drug, like morphine to release. Our research showed that LCA can effectively …

Aim The effects of diosmin (DS), pentoxifylline (PTX) and their combination on inflammatory
response, oxidant/antioxidant balance, cytoglobin and cirrhotic reaction during bile duct …

Chronic cholestasis liver injury occurs in progressive hepatobiliary diseases that eventually
lead to end-stage liver problems without curable treatment. Great advances in the molecular …

The acute or chronic administration of opioid drugs may induce oxidative damage and
cellular apoptosis in the liver and kidney, and hence result in hepatic and renal damage …

Arterial vasodilation with concomitant hyperdynamic circulation is a common finding in
cirrhotic subjects. Elevated levels of plasma endogenous opioid peptides have been …

Small-and intermediate-conductance Ca 2+-activated K+ channels, K Ca 2.3 and K Ca 3.1,
are involved in cellular signaling processes associated with inflammation and fibrosis. K Ca …