Objective Previous studies have found that sildenafil produces antinociception in
experimental models. This work was undertaken to determine the participation of the …

Naltrexone, an opioid receptor antagonist, has been claimed to have anti-inflammatory and
immunomodulatory effects both in vitro and in vivo. Thus, the aim of this study was to …

Plumbagin, a natural bicyclic naphthoquinone, has diverse pharmacological properties and
biological benefits against a number of disorders, including liver disease. Though …

Background and aim Oxidative stress (OS) is accused in pathogenesis of many diseases,
including liver cirrhosis by many mechanisms. One of them is the disturbance of long non …

Oxidative stress and the nitric oxide (NO) pathway are involved in the development of opioid
analgesic tolerance and dependence. Simvastatin modulates NO and oxidative stress, so …

Hepatic ischemia/reperfusion injury (IRI) remains a severe threat during liver surgery and
transplantation, accounting for unfavorable clinical outcomes. Modafinil (MOD), a …

Abstract Aims/Background: There are increasing number of evidences indicating the
contribution of endogenous opioids in the pathophysiology of cholestatic liver disease. The …

Sixty-one palmatine (PMT) derivatives, of which twenty-eight were new, were synthesized
and evaluated for their anti-fibrogenic activities via collagen type I α 1 (COL1A1)-promoter …

Hepatic fibrosis is one of the major worldwide health concerns which requires tremendous
research due to the limited outcomes of the current therapies. The present study was …

Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD). NASH is distinguished by severe hepatic fibrosis and inflammation. The …