MHC-encoded molecules govern adaptive immune responses by presenting peptides to T
cell receptors (TCRs). Based on TCR–MHC crystal structures, we revisit the extent of TCR …

MHC-encoded molecules govern immune responses by presenting antigenic peptides to T-
cell receptors (TCRs). Several crystal structures of TCR–pMHC (peptide–MHC) complexes …

TCR recognition of MHC/peptide complexes directs many aspects of T cell biology, including
thymic selection, survival of naı̈ve T cells and differentiation into effector and memory T …

Mature αβ T cells recognize foreign antigenic peptides presented by MHC molecules but do
not recognize native antigenic proteins; features known as MHC restriction. How MHC …

In contrast to antibodies, which recognize antigens in native form, αβ T cell receptors (TCRs)
only recognize antigens as peptide fragments bound to MHC molecules, a feature known as …

αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged …

T cell receptors (TCR) dock on their peptide-major histocompatibility complex (pMHC)
targets in a conserved orientation. Since amino acid sidechains are the foundation of …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

The rules for the conserved reaction of αβ T cell receptors (TCRs) with major
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …

The structure and amino acid diversity of the T‐cell receptor (TCR), similar in nature to that of
Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity …