Genomics of high-grade neuroendocrine neoplasms: well-differentiated neuroendocrine tumor with high-grade features (G3 NET) and neuroendocrine carcinomas …

S Uccella, S La Rosa, J Metovic, D Marchiori… - Endocrine …, 2021 - Springer
High-grade neuroendocrine neoplasms (HG-NENs) are clinically aggressive diseases, the
classification of which has recently been redefined. They now include both poorly …

Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites

TY Sun, L Zhao, P Van Hummelen… - Endocrine-related …, 2022 - erc.bioscientifica.com
High-grade (grade 3) neuroendocrine neoplasms (G3 NENs) have poor survival outcomes.
From a clinical standpoint, G3 NENs are usually grouped regardless of primary site and …

[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …

G Rindi, DS Klimstra, B Abedi-Ardekani, SL Asa… - Modern Pathology, 2018 - Elsevier
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

Well-differentiated neuroendocrine tumors with a morphologically apparent high-grade component: a pathway distinct from poorly differentiated neuroendocrine …

LH Tang, BR Untch, DL Reidy, E O'Reilly, D Dhall… - Clinical Cancer …, 2016 - AACR
Purpose: Most well-differentiated neuroendocrine tumors (WD-NET) of the enteropancreatic
system are low-intermediate grade (G1, G2). Elevated proliferation demonstrated by either a …

The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap

DS Klimstra, H Beltran, R Lilenbaum… - American Society of …, 2015 - ascopubs.org
Neuroendocrine neoplasms are diverse in terms of sites of origin, functional status, and
degrees of aggressiveness. This review will introduce some of the common features of …

Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies

K Kawasaki, N Rekhtman… - Nature Reviews …, 2023 - nature.com
Neuroendocrine neoplasms (NENs) can develop in almost any organ and span a spectrum
from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated …

Neuroendocrine neoplasm update: toward universal nomenclature

G Rindi, F Inzani - Endocrine-related cancer, 2020 - erc.bioscientifica.com
Neuroendocrine neoplasia is described in almost every tissue, either in the pure endocrine
organs, the nerve structures or in the so-called diffuse neuroendocrine system. The current …

GEP-NETS UPDATE: Genetics of neuroendocrine tumors

J Crona, B Skogseid - European journal of endocrinology, 2016 - academic.oup.com
Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms, arising from
neuroendocrine cells that are dispersed throughout the body. Around 20% of NETs occur in …

Neuroendocrine neoplasms of lung, pancreas and gut: a morphology-based comparison

A Kasajima, G Klöppel - Endocrine-Related Cancer, 2020 - erc.bioscientifica.com
The bronchopulmonary (BP) and gastroenteropancreatic (GEP) organ systems harbor the
majority of the neuroendocrine neoplasms (NENs) of the body, comprising 20 and 70% of all …

Genetic and epigenetic drivers of neuroendocrine tumours (NET)

A Di Domenico, T Wiedmer, I Marinoni… - Endocrine-related …, 2017 - erc.bioscientifica.com
Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical …