Comprehensive genomic profiling of neuroendocrine carcinomas of the gastrointestinal system

S Yachida, Y Totoki, M Noë, Y Nakatani, M Horie… - Cancer discovery, 2022 - AACR
The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly
malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing …

The problem of high-grade gastroenteropancreatic neuroendocrine neoplasms: well-differentiated neuroendocrine tumors, neuroendocrine carcinomas, and beyond

H Sorbye, E Baudin, A Perren - Endocrinology and Metabolism …, 2018 - endo.theclinics.com
Background The 2010 World Health Organization (WHO) classification of
gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) introduced morphology …

Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma

A Ooki, H Osumi, K Fukuda, K Yamaguchi - Cancer and Metastasis …, 2023 - Springer
Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …

An analysis of 130 neuroendocrine tumors G3 regarding prevalence, origin, metastasis, and diagnostic features

A Kasajima, B Konukiewitz, AM Schlitter, W Weichert… - Virchows Archiv, 2022 - Springer
Limited data exist on high-grade neuroendocrine tumors (NETs G3) which represent a new
category among neuroendocrine neoplasms (NEN). We analyzed NETs G3 in a consultation …

Molecular challenges of neuroendocrine tumors

P Patel, K Galoian - Oncology letters, 2018 - spandidos-publications.com
Neuroendocrine tumors (NETs) are a very heterogeneous group that are thought to originate
from the cells of the endocrine and nervous systems. These tumors develop in a number of …

Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis

V Melone, A Salvati, D Palumbo, G Giurato… - Journal of translational …, 2022 - Springer
Abstract Background Neuroendocrine neoplasms (NENs) represent a heterogeneous class
of rare tumors with increasing incidence. They are characterized by the ability to secrete …

Neuroendocrine tumors, version 1.2015

MH Kulke, MH Shah, AB Benson, E Bergsland… - Journal of the National …, 2015 - jnccn.org
Neuroendocrine tumors (NETs) comprise a broad family of tumors that may or may not be
associated with symptoms attributable to hormonal hypersecretion. The NCCN Clinical …

Diagnostic and prognostic implications of the World Health Organization classification of neuroendocrine tumors

A Faggiano, G Mansueto, P Ferolla, F Milone… - Journal of …, 2008 - Springer
Background: Neuroendocrine differentiation of tumors is often difficult to establish. In the
same manner, the evaluation of the prognostic role of neuroendocrine differentiation may …

Molecular pathology and genetics of gastrointestinal neuroendocrine tumours

MA Lewis, JC Yao - Current Opinion in Endocrinology, Diabetes …, 2014 - journals.lww.com
Molecular pathology and genetics of gastrointestinal neuroen... : Current Opinion in
Endocrinology, Diabetes and Obesity Molecular pathology and genetics of gastrointestinal …

The clinicopathologic heterogeneity of grade 3 gastroenteropancreatic neuroendocrine neoplasms: morphological differentiation and proliferation identify different …

M Milione, P Maisonneuve, F Spada… - …, 2016 - karger.com
Abstract Background/Aims: Gastroenteropancreatic (GEP) neuroendocrine carcinomas
(NECs) are defined as neuroendocrine neoplasms (NENs) with a Ki-67 index> 20 …