Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …

Epigenetic regulations play a crucial role in the expression of various genes that are
important in the normal cell function. Any alteration in these epigenetic mechanisms can …

Abnormalities in the epigenetic regulation of chromatin structure and function can lead to
aberrant gene expression and cancer development. Consequently, epigenetic therapies aim …

The identification of all epigenetic modifications implicated in gene expression is the next
step for a better understanding of human biology in both normal and pathological states …

Cancer is one of the most common human diseases. It is long known that mutations in key
regulator genes are hallmarks of all cancer types. Apart from these classical genetic …

Oncogenesis is a multistep process mediated by a variety of factors including epigenetic
modifications. Global epigenetic post-translational modifications have been detected in …

Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

Epigenetic regulation of gene expression is a dynamic and reversible process with DNA
methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking …

Interest in epigenetics is now booming in all the biomedical fields. Initially, interest was
sparked within the field of cancer research with the finding of global DNA hypomethylation …