Cholesterol modulates membrane properties and the interaction of gp41 fusion peptide to promote membrane fusion
An envelope glycoprotein, gp41, is crucial for the entry of human immunodeficiency virus
(HIV) into the host cell. The 20–23 N-terminal amino acid sequence of gp41 plays an …
(HIV) into the host cell. The 20–23 N-terminal amino acid sequence of gp41 plays an …
Unsaturated lipid accelerates formation of oligomeric β-sheet structure of GP41 fusion peptide in model cell membrane
W Wang, J Tan, S Ye - The Journal of Physical Chemistry B, 2020 - ACS Publications
Membrane fusion of the viral and host cell membranes is the initial step of virus infection and
is catalyzed by fusion peptides. Although the β-sheet structure of fusion peptides has been …
is catalyzed by fusion peptides. Although the β-sheet structure of fusion peptides has been …
Molecular dynamics simulation of HIV-1 fusion domain-membrane complexes: Insight into the N-terminal gp41 fusion mechanism
S Promsri, GM Ullmann, S Hannongbua - Biophysical Chemistry, 2012 - Elsevier
To understand how viral proteins fuse with the cell membrane, a process that is important for
the initial stages of infection, the conformation of the membrane-bound viral fusion peptides …
the initial stages of infection, the conformation of the membrane-bound viral fusion peptides …
Combination of Oleic Acid and the gp41 Fusion Peptide Switches the Phosphatidylethanolamine-Induced Membrane Fusion Mechanism from a Nonclassical to a …
A Joardar, GP Pattnaik… - The Journal of Physical …, 2022 - ACS Publications
Membrane fusion is considered to be one of the crucial processes for the existence of
eukaryotes and the entry of enveloped viruses into host cells. The fusion mechanism …
eukaryotes and the entry of enveloped viruses into host cells. The fusion mechanism …
Effect of cholesterol on the interaction of the HIV GP41 fusion peptide with model membranes. Importance of the membrane dipole potential
V Buzón, J Cladera - Biochemistry, 2006 - ACS Publications
Fusion of viral and cell membranes is a key event in the process by which the human
immunodeficiency virus (HIV) enters the target cell. Membrane fusion is facilitated by the …
immunodeficiency virus (HIV) enters the target cell. Membrane fusion is facilitated by the …
Destabilization of lipid membranes by a peptide derived from glycoprotein gp36 of feline immunodeficiency virus: a combined molecular dynamics/experimental study
Viral fusion glycoproteins present a membrane-proximal external region (MPER) which is
usually rich in aromatic residues and exhibits a marked tendency to stably reside at the …
usually rich in aromatic residues and exhibits a marked tendency to stably reside at the …
Cholesterol interaction with the trimeric HIV fusion protein gp41 in lipid bilayers investigated by solid-state NMR spectroscopy and molecular dynamics simulations
HIV-1 entry into cells is mediated by the fusion protein gp41. Cholesterol plays an important
role in this virus–cell fusion, but molecular structural information about cholesterol–gp41 …
role in this virus–cell fusion, but molecular structural information about cholesterol–gp41 …
Functional and structural characterization of HIV-1 gp41 ectodomain regions in phospholipid membranes suggests that the fusion-active conformation is extended
O Korazim, K Sackett, Y Shai - Journal of molecular biology, 2006 - Elsevier
HIV-1 entry into its host cell involves a sequential interaction whereby gp41 is in direct
contact with the plasma membrane. Understanding the effect of membrane composition on …
contact with the plasma membrane. Understanding the effect of membrane composition on …
A small-angle neutron scattering study of the physical mechanism that drives the action of a viral fusion peptide
WT Heller - Chemistry and Physics of Lipids, 2021 - Elsevier
Viruses have evolved a variety of ways for delivering their genetic cargo to a target cell. One
mechanism relies on a short sequence from a protein of the virus that is referred to as a …
mechanism relies on a short sequence from a protein of the virus that is referred to as a …
[HTML][HTML] Membrane curvature and surface area per lipid affect the conformation and oligomeric state of HIV-1 fusion peptide: a combined FTIR and MD simulation …
Fourier-transformed infrared spectroscopy (FTIR) and molecular dynamics (MD) simulation
results are presented to support our hypothesis that the conformation and the oligomeric …
results are presented to support our hypothesis that the conformation and the oligomeric …