Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and
eventual transection (axotomy). Neurons can survive axotomy, yet the underlying …

Axonal transaction provides very useful paradigms to study cellular responses to injury,
mechanisms of regeneration and plasticity, and processes that lead to nerve cell …

The transection of the axon of central neurons has dramatic consequences on the damaged
cells and nerves. Injury activates molecular programs leading to a complex repertoire of …

Traumatic injury often results in axonal severance, initiating obligatory Wallerian
degeneration of distal segments, whereas proximal segments often survive. Calcium ion …

Traumatic brain injuries are a leading cause of morbidity and mortality worldwide. With
almost 50% of traumatic brain injuries being related to axonal damage, understanding the …

Mild traumatic brain injury (mTBI) has been associated with the damage to myelinated axons
in white matter tracts. Animal models and in vitro studies suggest that axonal degradation …

Spinal cord injury leads to persistent behavioral deficits because mammalian central
nervous system axons fail to regenerate. A neuron's response to axon injury results from a …

Traumatic cerebral or spinal cord injury induced by military, traffic, and sports accidents, falls
or environmental and anthropogenic catastrophes are among main causes of people …

Publisher Summary Neurons in the central and peripheral nervous system show various
responses to axotomy, ranging from cell death or severe atrophy without axon regeneration …

Diffuse axonal injury (DAI), a major component of traumatic brain injury, is characterized by
a sequence of neurochemical reactions initiated at the time of trauma and resulting in axonal …