The inability to repair the damaged membrane may be one of the key mechanisms
underlying the severe neuronal degeneration and overall functional loss seen in in vivo …

The synaptic terminals' withdrawal from the somata and proximal dendrites of injured
motoneuron by the processes of glial cells following facial nerve axotomy has been the …

The axonal and synaptic mechanisms underlying dysfunction and repair of the injured CNS
are poorly understood. Unresolved issues include to what degree, when, and how the …

Following spinal root injury, dorsal root ganglia suffer mechanical trauma and compromised
blood supply. Little is known about the consequences for neuronal survival. Here we used …

Traumatic axonal injury (TAI) is one of the most important pathologies associated with
closed head injury, and contributes to ensuing morbidity. The authors evaluated the …

The acute response of neurons subjected to traumatic loading involves plasma membrane
disruption, yet the mechanical tolerance for membrane compromise, time course, and …

Severed CNS axons often retract or dieback away from the injury site and fail to regenerate.
The precise mechanisms underlying acute axonal dieback and secondary axonal …

We have previously presented evidence that the development of secondary traumatic
axonal injury is related to the degree of local cerebral blood flow (LCBF) and flow …

Although axonal injury is a common feature of brain trauma, little is known of the immediate
morphological responses of individual axons to mechanical injury. Here, we developed an …

During regeneration of injured peripheral nerves, local conditions may influence how
regenerative axon sprouts emerge from parent axons. More extensive lesions might be …