The heightened cardiovascular disease (CVD) risk observed among omnivores is thought to
be linked, in part, to gut microbiota-dependent generation of trimethylamine-N-oxide (TMAO) …

L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a
metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host …

BACKGROUND. l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis
in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine …

Intestinal microbiota metabolism of choline and phosphatidylcholine produces
trimethylamine (TMA), which is further metabolized to a proatherogenic species …

l-Carnitine is a common food supplement and naturally occurs in red meat. This nutrient is
metabolized into trimethyl metabolites by the gut microbiota and is associated with an …

In recent years, a number of studies have alluded to the importance of the intestinal
microflora in controlling whole-body metabolic homeostasis and organ physiology. In …

Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link
between red meat intake and poor cardiometabolic health. We investigated whether gut …

Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which upon absorption by the host …

Background Dietary nutrient intake and its metabolism by the gut microbiome have recently
been implicated in cardiovascular disease (CVD) risk. In particular, trimethylamine N-oxide …

Our group recently discovered that certain dietary nutrients possessing a trimethylamine
(TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the …