Antimicrobial susceptibility tests (AST) are based on the minimal inhibitory concentration
(MIC), the method used worldwide to guide antimicrobial therapy. Despite its relevance in …

Background The minimum inhibitory concentration (MIC) is a measure of antimicrobial
susceptibility testing (AST) of a given antibiotic but provides insufficient information when …

Inefficiency of medical therapies used in order to cure patients with bacterial infections
requires not only to actively look for new therapeutic strategies but also to carefully select …

Clinical breakpoints are used in clinical microbiology laboratories to categorize
microorganisms as clinically susceptible (S), intermediate (I) or resistant (R) dependent on …

Bacterial resistance to antibiotics continues to be a global public health problem. The choice
of the most effective antibiotic and the use of an adapted dose in the initial phase of the …

Interpretive criteria for in vitro susceptibility testing criteria,“susceptibility breakpoints,”
underpin the evaluation and selection of antimicrobial regimens. However, despite their …

Since the origin of an"'International Collaborative Study on Antibiotic Sensitivity Testing'" in
1971, considerable advancement has been made to standardize clinical susceptibility …

Ever since the use of antimicrobials began, methods and indicators have been sought that in
some way could predict the outcome of antimicrobial treatment of infections, and thereby be …

The interpretation of 'susceptible (S)'or 'resistant (R)'results of antimicrobial susceptibility
testing is easily understood, but the interpretation of the 'intermediate (I)'category can be …

Due to variability in pharmacokinetics and pharmacodynamics, clinical outcomes of
antimicrobial drug therapy vary between patients. As such, personalised medication …