Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway

Y Gu, S Duan, M Ding, Q Zheng, G Fan, X Li, Y Li, C Liu… - Phytomedicine, 2022 - Elsevier
Background Metabolic associated fatty liver disease (MAFLD) is a progressive chronic liver
disease, yet there is still a lack of effective pharmacological therapies at present …

[HTML][HTML] Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease

X Li, J Ge, Y Li, Y Cai, Q Zheng, N Huang, Y Gu… - … Pharmaceutica Sinica B, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes of
chronic liver diseases and malignancies. However, few therapy has been approved. Radix …

Saikosaponins ameliorate hyperlipidemia in rats by enhancing hepatic lipid and cholesterol metabolism

Q Zheng, X Li, N Huang, F Li, J Ge, D Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Hyperlipidemia is the systemic manifestation of abnormal
lipid metabolism, characterized by elevated circulating levels of cholesterol and triglyceride …

Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway

LS Yan, SF Zhang, G Luo, BCY Cheng, C Zhang… - Metabolism, 2022 - Elsevier
Abstract Background Schisandrin B (Sch B), which inhibits hepatic steatosis caused by non-
alcoholic fatty liver disease (NAFLD), is one of the most active dibenzocyclooctadienes …

Akebia saponin D decreases hepatic steatosis through autophagy modulation

L Gong, G Li, W Zhang, H Liu, Y Lv, F Han, Z Wan… - … of Pharmacology and …, 2016 - ASPET
Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of the
metabolic syndrome, and the incidence of NAFLD is increasing rapidly. However …

[HTML][HTML] The ameliorative effects of saikosaponin in thioacetamide-induced liver injury and non-alcoholic fatty liver disease in mice

GR Chang, WL Lin, TC Lin, HJ Liao, YW Lu - International journal of …, 2021 - mdpi.com
Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …

Shenge Formula attenuates high-fat diet-induced obesity and fatty liver via inhibiting ACOX1

Z Shang, Y Gao, Y Xue, C Zhang, J Qiu, Y Qian… - Phytomedicine, 2024 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver
disease worldwide. Shenge Formula (SGF) is a traditional Chinese medicine that has been …

Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor

X Duan, Q Meng, C Wang, Z Liu, Q Liu, H Sun, P Sun… - Phytomedicine, 2017 - Elsevier
Background Non-alcoholic steatohepatitis (NASH) represents the more severe end of
hepatic steatosis and is associated with progressive liver disease. Calycosin, derived from …

[HTML][HTML] Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells

K Fang, F Wu, G Chen, H Dong, J Li, Y Zhao… - … and alternative medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease and is characterized by excessive hepatic lipid accumulation. Many studies have …

[HTML][HTML] Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway

Y Li, Y Liu, Z Chen, K Tang, L Yang, Y Jiang… - Biomedicine & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the main chronic liver
diseases worldwide. Protopanaxadiol (PPD), an active compound derived from …