[HTML][HTML] Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy

L Gong, S Yang, W Zhang, F Han, Y Lv, ZR Wan… - Journal of …, 2018 - Elsevier
Abstract Akebia Saponin D (ASD) is the most abundant constituent of the rhizome of
Dipsacus asper Wall. The prior studies have shown that ASD alleviates hepatic steatosis …

An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a …

S Park, JE Lee, SM Lee, J Lee, CS Seo… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Dohongsamul-tang (DST) is a traditional herbal formula
used to promote the blood circulation and inhibit inflammation, and also widely has been …

Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using melanocortin 4 receptor-deficient mice

K Konuma, M Itoh, T Suganami, S Kanai… - PLoS …, 2015 - journals.plos.org
Many attempts have been made to find novel therapeutic strategies for non-alcoholic
steatohepatitis (NASH), while their clinical efficacy is unclear. We have recently reported a …

Meroterpenoid-rich fraction of an ethanolic extract from Sargassum serratifolium alleviates obesity and non-alcoholic fatty liver disease in high fat-fed C57BL/6J mice

M Kwon, SJ Lim, EJ Joung, B Lee, CW Oh… - Journal of Functional …, 2018 - Elsevier
Sargassum serratifolium has diverse health-promoting effects because of high levels of
meroterpenoids with strong antioxidant and anti-inflammatory activities. Here, we …

Mixture of Peanut Skin Extract, Geniposide, and Isoquercitrin Improves the Hepatic Lipid Accumulation of Mice via Modification of Gut Microbiota Homeostasis and the …

M Yi, OB Fasina, Y Li, L Xiang, J Qi - International Journal of Molecular …, 2023 - mdpi.com
Metabolic-dysfunction-associated steatotic liver disease (MASLD, formerly known as
NAFLD) is a global chronic liver disease, and no licensed drugs are currently available for …

Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway

J Liao, X Xie, N Wang, Y Wang, J Zhao, F Chen, F Qu… - Phytomedicine, 2024 - Elsevier
Background Non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic
fatty liver disease (NAFLD), carries a high risk of cirrhosis and hepatocellular carcinoma …

Sesamol ameliorates diet‐induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3‐L1 cells via regulating mitochondria‐lipid metabolism

Z Liu, Q Qiao, Y Sun, Y Chen, B Ren… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope The aim of the current study was to investigate the effect of sesamol, a natural
powerful antioxidant and anti‐inflammatory phenol derivative of sesame oil, on adiposity …

Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c

G Li, F Zhou, Y Chen, W Zhang, N Wang - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) refers to a pathological condition of hepatic
steatosis. Insulin resistance is believed to be the key mechanism mediating initial …

Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL

P Li, Y Chen, X Ke, R Zhang, L Zuo, M Wang… - Archives of Biochemistry …, 2022 - Elsevier
Baicalin is a flavonoid compound abundant in multiple edible and medicinal plants such as
Scutellaria baicalensis Georgi. In this study, we provide evidence to support the fact that …

Madecassoside ameliorates hepatic steatosis in high-fat diet-fed mice through AMPK/autophagy-mediated suppression of ER stress

SW Choi, W Cho, H Oh, AM Abd El-Aty, SA Hong… - Biochemical …, 2023 - Elsevier
Hepatic endoplasmic reticulum (ER) stress is a contributing factor in the development of
hepatic steatosis in obesity. Madecassoside (MA), a pentacyclic triterpene derived from …