Background This study aimed to understand the mechanistic role of N-methyl-D-aspartate
receptor (NMDAR) in acute fibrogenesis using models of in vivo ureter obstruction and in …

Background Renal fibrosis is characterized by excessive production and deposition of
extracellular matrix (ECM), which leads to progressive renal failure. Adenosine …

Renal fibrosis is a common pathological hallmark of chronic kidney disease (CKD). Renal
sympathetic nerve activity is elevated in patients and experimental animals with CKD and …

Background Renal interstitial fibrosis (RIF) is a common pathway to end-stage renal disease
regardless of the initial etiology. Currently, the molecular mechanisms for RIF remains not …

Fibrosis of the glomerular and tubulointerstitial compartments is a common feature of chronic
kidney disease leading to end-stage renal failure. This fibrotic process involves a number of …

Epithelial–mesenchymal transition (EMT) contributes to the progression of renal
tubulointerstitial fibrosis. The N-methyl-D-aspartate receptor (NMDAR), which is present in …

Interstitial fibrosis is a typical feature of all progressive renal diseases. The process of
fibrosis is frequently coupled with the presence of pro‑fibrotic factors and inflammation …

Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases
currently lacking effective treatment. Nicotinamide (NAM), a member of water‐soluble …

Chronic kidney disease (CKD), a disease involving damage to the kidney structure and
function, is a global public health problem. Tubulointerstitial fibrosis (TIF) is both an …

TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling
pathway is a possible therapeutic approach for preventing this disease, and reports have …