Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
A Neesse, CA Bauer, D Öhlund, M Lauth, M Buchholz… - Gut, 2019 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
Stromal biology and therapy in pancreatic cancer: a changing paradigm
A Neesse, H Algül, DA Tuveson, TM Gress - Gut, 2015 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
A Neesse, S Krug, TM Gress, DA Tuveson… - OncoTargets and …, 2013 - Taylor & Francis
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat.
Over recent years, it has become increasingly evident that the complex network of soluble …
Over recent years, it has become increasingly evident that the complex network of soluble …
Pancreatic cancer microenvironment and cellular composition: current understandings and therapeutic approaches
LH Truong, S Pauklin - Cancers, 2021 - mdpi.com
Simple Summary There is currently no effective treatment for Pancreatic Ductal
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …
[HTML][HTML] Microenvironmental determinants of pancreatic cancer
E Hessmann, SM Buchholz, IE Demir… - Physiological …, 2020 - journals.physiology.org
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer
Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …
[HTML][HTML] The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities
WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
[HTML][HTML] The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions
CJ Herting, I Karpovsky, GB Lesinski - Cancer and Metastasis Reviews, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and is
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …
[HTML][HTML] Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies
AA Rucki, L Zheng - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …
Stromal biology and therapy in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is an almost uniformly lethal disease. One
explanation for the devastating prognosis is the failure of many chemotherapies, including …
explanation for the devastating prognosis is the failure of many chemotherapies, including …