Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

A Neesse, CA Bauer, D Öhlund, M Lauth, M Buchholz… - Gut, 2019 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …

Stromal biology and therapy in pancreatic cancer: a changing paradigm

A Neesse, H Algül, DA Tuveson, TM Gress - Gut, 2015 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

A Neesse, S Krug, TM Gress, DA Tuveson… - OncoTargets and …, 2013 - Taylor & Francis
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat.
Over recent years, it has become increasingly evident that the complex network of soluble …

Pancreatic cancer microenvironment and cellular composition: current understandings and therapeutic approaches

LH Truong, S Pauklin - Cancers, 2021 - mdpi.com
Simple Summary There is currently no effective treatment for Pancreatic Ductal
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …

[HTML][HTML] Microenvironmental determinants of pancreatic cancer

E Hessmann, SM Buchholz, IE Demir… - Physiological …, 2020 - journals.physiology.org
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …

Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer

A Bulle, KH Lim - Signal Transduction and Targeted Therapy, 2020 - nature.com
Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …

[HTML][HTML] The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities

WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

[HTML][HTML] The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions

CJ Herting, I Karpovsky, GB Lesinski - Cancer and Metastasis Reviews, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and is
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …

[HTML][HTML] Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies

AA Rucki, L Zheng - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …

Stromal biology and therapy in pancreatic cancer

A Neesse, P Michl, KK Frese, C Feig, N Cook… - Gut, 2011 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) is an almost uniformly lethal disease. One
explanation for the devastating prognosis is the failure of many chemotherapies, including …