Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Hyperphosphatemia is a common complication in patients with chronic kidney disease
(CKD), particularly in those requiring renal replacement therapy. The importance of …

Hyperphosphatemia has consistently been shown to be associated with dismal outcome in a
wide variety of populations, particularly in chronic kidney disease (CKD). Compelling …

Serum phosphorus levels stay relatively constant through the influence of multiple factors—
such as parathyroid hormone, fibroblast growth factor 23, and vitamin D—on the kidney …

Chronic kidney disease (CKD)–mineral and bone disorder is associated with diverse
metabolic and endocrine disturbances that ultimately may contribute to further loss of kidney …

Careful dietary management that reduces high phosphate intake is recommended to slow
the progression of chronic kidney disease (CKD) and prevent complications of CKD and …

The kidneys excrete excess dietary phosphate, and patients with chronic kidney disease
may suffer from phosphate overload and hyperphosphatemia. In chronic kidney disease …

Maintenance of a normal serum phosphate level depends on absorption in the gut,
reabsorption and excretion by the kidney, and the flux between the extracellular and skeletal …

There is an intimate association between mineral and bone disorders in chronic kidney
disease (CKD) and the extensive burden of cardiovascular disease (CVD) in this population …