Social defeat-induced increase in the conditioned rewarding effects of cocaine: Role of CX3CL1

S Montagud-Romero, J Montesinos, FJ Pavón… - Progress in Neuro …, 2020 - Elsevier
Social stress is associated with higher vulnerability to drug use, as it enhances the
reinforcing effects of psychostimulants in rodents. Furthermore, continued or severe stress …

Cocaine-induced changes in CX3CL1 and inflammatory signaling pathways in the hippocampus: Association with IL1β

J Montesinos, E Castilla-Ortega, L Sánchez-Marín… - …, 2020 - Elsevier
Cocaine induces neuroinflammatory response and interleukin-1 beta (IL1β) is suggested a
final effector for many cocaine-induced inflammatory signals. Recently, the chemokine …

Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects

R Ballestín, L Alegre-Zurano, C Ferrer-Pérez… - Progress in Neuro …, 2021 - Elsevier
Using the social defeat (SD) model, numerous studies have shown that stressed mice
display an enhanced response to the motivational effects of cocaine in the self …

[HTML][HTML] Behavioral traits associated with resilience to the effects of repeated social defeat on cocaine-induced conditioned place preference in mice

C Calpe-López, MP García-Pardo… - Frontiers in behavioral …, 2020 - frontiersin.org
The relationship between stress and drug use is well demonstrated. Stress-induced by
repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by …

Acute social defeat stress increases the conditioned rewarding effects of cocaine in adult but not in adolescent mice

S Montagud-Romero, MA Aguilar, C Maldonado… - Pharmacology …, 2015 - Elsevier
Stressful experiences modify activity in areas of the brain involved in the rewarding effects of
psychostimulants. In the present study we evaluated the influence of acute social defeat …

[HTML][HTML] Behavioural traits related with resilience or vulnerability to the development of cocaine-induced conditioned place preference after exposure of female mice to …

MÁ Martínez-Caballero, C Calpe-López… - Progress in Neuro …, 2024 - Elsevier
Exposure to stress induced by intermittent repeated social defeat (IRSD) increases
vulnerability to the development of cocaine-induced conditioned place preference (CPP) …

[HTML][HTML] Resilience to social defeat stress in adolescent male mice

MD Reguilón, R Ballestín, J Miñarro… - Progress in Neuro …, 2022 - Elsevier
Adverse social experiences during adolescence are associated with the appearance of
mental illness in adulthood. Social defeat (SD) is an ethologically valid murine model to …

[HTML][HTML] Indomethacin blocks the increased conditioned rewarding effects of cocaine induced by repeated social defeat

C Ferrer-Pérez, TE Martinez, S Montagud-Romero… - PLoS …, 2018 - journals.plos.org
It is well established that repeated social defeat stress can induce negative long-term
consequences such as increased anxiety-like behavior and enhances the reinforcing effect …

Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB …

S Montagud-Romero, C Nuñez, MC Blanco-Gandia… - …, 2017 - Springer
Rationale Repeated social defeat (RSD) increases the rewarding effects of cocaine in
adolescent and adult rodents. Objective The aim of the present study was to compare the …

Social interaction reward in rats has anti‐stress effects

C Lemos, A Salti, IM Amaral, V Fontebasso… - Addiction …, 2021 - Wiley Online Library
Social interaction in an alternative context can be beneficial against drugs of abuse. Stress
is known to be a risk factor that can exacerbate the effects of addictive drugs. In this study …