Although the effect of NSAIDs such as celecoxib on the progression of colorectal polyps has
been established, it is currently unknown how sufficiently high concentrations of celecoxib …

NSAIDs such as celecoxib and sulindac play a critical role in the treatment of colorectal
cancer, yet it is not understood how sufficiently high concentrations are reached in colonic …

Nonsteroidal anti-inflammatory drugs have potential for use in the prevention and/or
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …

In general, colon-specific delivery of a drug decreases systemic absorption and increases
therapeutic concentration of the drug at the target site. N-succinylglutam-1 or 5-yl celecoxib …

To develop a colon-specific prodrug of celecoxib, a cyclooxygenase-2 selective inhibitor,
which could improve cardiovascular toxicity and therapeutic effectiveness for …

Celecoxib pharmacokinetics was evaluated after single and multiple oral dosing; after
dosing in a solution and as a solid; with and without food; and after administration into …

The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-
methylphenyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl] benzenesulfonamide, a cyclooxygenase …

Celecoxib is a selective cyclooxygenase-2-(COX-2)-inhibitor used to treat inflammation and
pain and prevents colorectal cancer in patients at high doses by affecting several non-COX …

Celecoxib, a selective cyclooxygenase-2 inhibitor, is potentially useful for the treatment of
colonic diseases such as colorectal cancer and colitis. However, the cardiovascular toxicity …

The outcome of advanced colorectal cancer (CRC) has steadily improved with the addition
of several novel agents. However, chemotherapy is associated with significant toxicities …