Primate lentiviruses including human immunodeficiency virus type 1 (HIV-1) and simian
immunodeficiency viruses (SIVs) evolved through the acquisition of antagonists against …

The interferon-induced host restriction factor tetherin poses a barrier for SIV transmission
from primates to humans. After cross-species transmission, the chimpanzee precursor of …

The host restriction factor tetherin inhibits virion release from infected cells and poses a
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …

Human immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans,
whereas most PLVs are less or not pathogenic in monkeys. These notions suggest that the …

Tetherin, also known as BST2, CD317 or HM1. 24, was recently identified as an interferon-
inducible host–cell factor that interferes with the detachment of virus particles from infected …

The multifunctional Nef protein of primate lentiviruses is commonly considered an early viral
factor that downmodulates various receptors from the cell surface and modulates several …

Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage
of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu …

Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their
nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC …

Although Nef is the viral gene product used by most simian immunodeficiency viruses to
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …

Most simian immunodeficiency viruses (SIVs) use Nef to counteract restriction by the tetherin
proteins of their nonhuman primate hosts. In addition to counteracting tetherin, SIV Nef has a …