Structural basis of flagellar filament asymmetry and supercoil templating by Leptospira spirochete sheath proteins

MR Brady, FS Martin, GE Debs, KH Gibson… - bioRxiv, 2022 - biorxiv.org
Several Leptospira species are bacterial agents of leptospirosis, a neglected tropical
disease responsible for~ 1 million cases and 50,000 deaths each year worldwide …

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

KH Gibson, F Trajtenberg, EA Wunder, MR Brady… - Elife, 2020 - elifesciences.org
Spirochete bacteria, including important pathogens, exhibit a distinctive means of swimming
via undulations of the entire cell. Motility is powered by the rotation of supercoiled' …

A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete

EA Wunder Jr, CP Figueira, N Benaroudj… - Molecular …, 2016 - Wiley Online Library
Leptospira are unique among bacteria based on their helical cell morphology with hook‐
shaped ends and the presence of periplasmic flagella (PF) with pronounced spontaneous …

Leptospiral flagellar sheath protein FcpA interacts with FlaA2 and FlaB1 in Leptospira biflexa

Y Sasaki, A Kawamoto, H Tahara, K Kasuga, R Sato… - PLoS …, 2018 - journals.plos.org
Leptospira spp. are spirochete bacteria that possess periplasmic flagella (PFs) underneath
the outer membrane; each flagellum is attached to each end of the protoplasmic cylinder …

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis

F San Martin, AE Mechaly, N Larrieux… - … Section F: Structural …, 2017 - journals.iucr.org
The protein FcpA is a unique component of the flagellar filament of spirochete bacteria
belonging to the genus Leptospira. Although it plays an essential role in translational motility …

Analysis of a Spontaneous Non-Motile and Avirulent Mutant Shows That FliM Is Required for Full Endoflagella Assembly in Leptospira interrogans

C Fontana, A Lambert, N Benaroudj, D Gasparini… - PLoS …, 2016 - journals.plos.org
Pathogenic Leptospira strains are responsible for leptospirosis, a worldwide emerging
zoonotic disease. These spirochetes are unique amongst bacteria because of their …

Characterization of the flagellar collar reveals structural plasticity essential for spirochete motility

Y Chang, H Xu, MA Motaleb, J Liu - Mbio, 2021 - Am Soc Microbiol
Spirochetes are a remarkable group of bacteria with distinct morphology and periplasmic
flagella that enable motility in viscous environments, such as host connective tissues. The …

FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira

EA Wunder Jr, L Slamti, DN Suwondo… - Frontiers in Cellular …, 2018 - frontiersin.org
The spirochete endoflagellum is a unique motility apparatus among bacteria. Despite its
critical importance for pathogenesis, the full composition of the flagellum remains to be …

A widely conserved bacterial cytoskeletal component influences unique helical shape and motility of the spirochete Leptospira biflexa

KM Jackson, C Schwartz, J Wachter… - Molecular …, 2018 - Wiley Online Library
Leptospires and other members of the evolutionarily ancient phylum of Spirochaetes are
bacteria often characterized by long, highly motile spiral‐or wave‐shaped cells. Morphology …

Diving into the complexity of the spirochetal endoflagellum

F San Martin, L Fule, G Iraola, A Buschiazzo… - Trends in …, 2023 - cell.com
Spirochaetes, a phylum that includes medically important pathogens such as the causative
agents of Lyme disease, syphilis, and leptospirosis, are in many ways highly unique …