Background: We have previously reported sputum YKL-40 could be a biomarker for
predicting neutrophilic airway inflammation in asthma, asthma-COPD overlap (ACO) and …

Background: We have previously reported sputum YKL-40 could be a biomarker for
predicting neutrophilic airway inflammation in asthma, COPD, and asthma-COPD overlap …

Background: Recent evidence suggests that YKL-40, also called chitinase-3-like-1 protein,
is involved in the pathogenesis of asthma and chronic obstructive pulmonary disease …

Background Many studies have found that YKL-40 may play an important pathogenic role in
COPD. However, the results of these studies were inconsistent. Therefore, we performed a …

■ Abstract Background: Serum chitinase-like proteins such as YKL-40 in asthmatic patients
are known to positively correlate with disease severity but controversy remains regarding …

Background Macrophages constitute a heterogeneous cell population with pro-(MΦ1) and
anti-inflammatory (MΦ2) cells. The soluble chitinase-like-protein YKL-40 is expressed in …

Background: YKL-40 is a member of the mammalian chitinase like protein class of 40 Kda
(kilo Dalton) heparin binding glycoprotein. Its name is derived from the protein's molecular …

Background: YKL-40 is a new marker that plays a role in tissue remodeling and airway
inflammatory processes. Objective: The objective wasevaluatingYKL-40 serum levels in …

Background Associations between levels of the chitinase-like protein YKL-40 (CHI3L1) and
airway inflammation and remodeling have been shown in adults (Chupp et al. NEJM 2007; …

Background Asthma is a heterogeneous chronic airway disease, which may be classified
into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but …