Targeting peripheral neuropathic pain at its origin may prevent the development of
hypersensitivity. Recently we showed this can be mediated by opioid receptors at the injured …

Introduction: With 336 reviews, the capsaicin receptor TRPV1 arguably represent today's
most extensively reviewed analgesic target. TRPV1 is strategically located at the peripheral …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel
activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory …

Neurogenic inflammation is produced by overstimulation of peripheral nociceptor terminals
by injury or inflammation of tissues. Excessive activity of sensory neurons produces …

Opiates are currently the mainstay for treatment of moderate to severe pain. However,
prolonged administration of opiates has been reported to elicit hyperalgesia in animals, and …

A major goal in pain research is the development of analgesics that would circumvent the
side effect and efficacy limitations of opioids and NSAIDs. Progress towards this goal has …

TRPV3 is a nonselective cation channel activated by temperatures above 33° C and is
reported to be localized in keratinocytes and nervous tissue. To investigate a role for TRPV3 …

TRPV1 (transient receptor potential vanilloid family type 1) is a nonselective cation channel
that is activated and/or sensitized by noxious heat, protons, and other endogenous …

Current therapy for inflammatory pain includes the peripheral application of opioid receptor
agonists. Activation of opioid receptors modulates voltage-gated ion channels, but it is …

Clinical data demonstrating target-mediated elevation of core body temperature in humans
have been a major setback in the development of TRPV1 antagonists as novel therapeutics …