The sheer size of the human genome makes it improbable that identical somatic mutations
at the exact same position are observed in multiple tumours solely by chance. The scarcity of …

The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …

Much remains unknown about the progression and heterogeneity of mutational processes in
different cancers and their diagnostic and clinical potential. A growing body of evidence …

Recent advances in technological tools for massively parallel, high-throughput sequencing
of DNA have enabled the comprehensive characterization of somatic mutations in a large …

Mutational signatures provide a powerful alternative for understanding the pathophysiology
of cancer. Currently, experimental efforts aimed at validating and understanding the …

Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes
are peppered with mutations. Although most somatic tumour mutations are unlikely to have …

Next generation sequencing technologies (NGS) have been critical in characterizing the
genomic landscape and untangling the genetic heterogeneity of human cancer. Since its …

The availability of the human genome sequence and progress in sequencing and
bioinformatic technologies have enabled genome-wide investigation of somatic mutations in …

Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

Background The nature of somatic mutations observed in human tumors at single gene or
genome-wide levels can reveal information on past carcinogenic exposures and mutational …