Elevated prolactin during pregnancy drives a phenotypic switch in mouse hypothalamic dopaminergic neurons

SH Yip, N Romano, P Gustafson, DJ Hodson… - Cell reports, 2019 - cell.com
Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a
sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons …

Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release

N Romano, SH Yip, DJ Hodson, A Guillou… - Journal of …, 2013 - Soc Neuroscience
Tuberoinfundibular dopamine (TIDA) neurons are the central regulators of prolactin (PRL)
secretion. Their extensive functional plasticity allows a change from low PRL secretion in the …

Opioid control of prolactin secretion in late pregnant rats is mediated by tuberoinfundibular dopamine neurons

ZB Andrews, DR Grattan - Neuroscience letters, 2002 - Elsevier
Prolactin (PRL) secretion from the anterior pituitary is tonically inhibited by
tuberoinfundibular dopamine (TIDA) neurons in the arcuate nucleus of the hypothalamus …

Pregnancy‐induced adaptation in the neuroendocrine control of prolactin secretion

DR Grattan, FJ Steyn, IC Kokay… - Journal of …, 2008 - Wiley Online Library
During pregnancy, neuroendocrine control of prolactin secretion is markedly altered to allow
a state of hyperprolactinaemia to develop. Prolactin secretion is normally tightly regulated by …

Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action

TJ Sapsford, IC Kokay, L Östberg… - Journal of …, 2012 - Wiley Online Library
Prolactin stimulates dopamine release from neuroendocrine dopaminergic (NEDA) neurons
in the hypothalamic arcuate nucleus (ARC) to maintain low levels of serum prolactin …

Plasticity of the prolactin (PRL) axis: mechanisms underlying regulation of output in female mice

PR Le Tissier, DJ Hodson, AO Martin… - Recent Advances in …, 2015 - Springer
The output of prolactin (PRL) is highly dynamic with dramatic changes in its secretion from
the anterior pituitary gland depending on prevailing physiological status. In adult female …

Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse

RSE Brown, AE Herbison, DR Grattan - Biology of reproduction, 2011 - academic.oup.com
During lactation, there are numerous functional adaptations in the maternal brain. There is
evidence that the high levels of circulating prolactin present during lactation might contribute …

Differential changes in the hypothalamic‐pituitary‐adrenal axis and prolactin responses to stress in early pregnant mice

VJ Parker, JRW Menzies… - Journal of …, 2011 - Wiley Online Library
Stress can cause pregnancy failure but it is unclear how the mother's neuroendocrine
system responds to stress to impair mechanisms establishing implantation. We analysed …

Prolactin receptors in the brain during pregnancy and lactation: implications for behavior

DR Grattan, XJ Pi, ZB Andrews, RA Augustine… - Hormones and …, 2001 - Elsevier
Numerous studies have documented prolactin regulation of a variety of brain functions,
including maternal behavior, regulation of oxytocin neurons, regulation of feeding and …

Regulation of prolactin secretion during pregnancy and lactation

JL Voogt, Y Lee, S Yang, L Arbogast - Progress in Brain Research, 2001 - Elsevier
Prolactin plays major roles in maintaining the corpora lutea of pregnancy and in the
synthesis of milk during lactation. The hypothalamic mechanisms involved in these functions …