Pancreatic cancer (PC) is a deadly cancer with a high mortality rate. The unique
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …

Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …

Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …

Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …

Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …

Background: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …

Simple Summary It has been previously shown that activation of the MET receptor by its
ligand, the hepatocyte growth factor (HGF), modulates the tumor-stroma cross-talk in models …

Simple Summary Pancreatic cancer (PC) has a poor prognosis. Even though surgical
resection and adjuvant chemotherapy is the most effective therapy, recurrence remains …

The pancreatic stellate cell (PSC) is the principal cell type of the desmoplastic stroma of
pancreatic ductal adenocarcinoma (PDAC). PSCs interact with cancer cells and influence …

Activated cancer-associated human pancreatic stellate cells (CAhPSCs, which produce the
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …