Pancreatic cancer is a disease with remarkably poor patient survival rates. The frequent
presence of metastases and profound chemoresistance pose a severe problem for the …

Pancreatic cancer is a highly lethal cancer characterized by local invasiveness, early
metastasis, recurrence and high resistance to current therapies. Extensive stroma or …

Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …

The hepatocyte growth factor/mesenchymal-epithelial transition factor (HGF/c-MET) receptor
tyrosine kinase (RTK) pathway plays a pleotropic role in cell proliferation, migration …

Pancreatic cancer is one of the leading causes of cancer-related death in the United States
and survival outcomes remain dismal despite significant advances in molecular diagnostics …

Pancreatic cancer is a leading cause of cancer-related death due to its invasive nature.
Despite the improvement of diagnostic strategy, early diagnosis of pancreatic cancer is still …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers, and is
known for its extremely poor prognosis. Because of the location and composition of the …

Advanced gastric cancer (GC) is a dreadful disease with a poor prognosis and the majority
of patients die within 1 year of diagnosis. In the past decade, important signaling pathways …

Pancreatic cancer shows a characteristic tissue structure called desmoplasia, which consists
of dense fibrotic stroma surrounding cancer cells. Interactions between pancreatic cancer …

Simple Summary The tumor microenvironment of pancreatic cancer consists of dense
fibrotic stroma, which, to a certain extent, accounts for the relative drug resistance of this …