Pancreatic cancer is the deadliest solid cancer and currently the fourth most frequent cause
of cancer-related deaths. Emerging evidence suggests that cancer stem cells (CSCs) play a …

Background aims. Because of the inflammatory nature and extensive stromal compartment
in pancreatic tumors, we investigated the role of mesenchymal stromal cells (MSC) to engraft …

Objective: To analyze the efficacy of engineered mesenchymal stem cell based therapy
directed towards pancreatic tumor stroma. Summary Background Data: Mesenchymal stem …

Background Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that
contribute to chemoresistant tumors prone to metastasis and recurrence. Drug screening …

Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with
pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However …

Research has highlighted the importance of the stroma in pancreatic cancer, in particular the
role of complex interactions between cancer and stromal cells. A new study describes a …

Background Pancreatic cancer is one of the most lethal malignancies. The innovative
treatments are required and now the cancer stem cells (CSCs) are expected to be an …

PURPOSE: Increased expression of the hepatocytes growth factor (HGF) receptor (c-Met)
and urokinase type plasminogen activator (uPA) correlate with the development and …

Despite the improved overall survival rates in most cancers, pancreatic cancer remains one
of the deadliest cancers in this decade. The rigid microenvironment, which majorly …

Pancreatic cancer (PC) is a fatal disease with high malignancy and difficult for early
diagnosis. PC causes more than 400,000 patient deaths world widely and becomes the …