Abstract Endothelin-1 (ET-1), a 21-amino acid peptide, was initially identified in 1988 as a
potent vasoconstrictor and pressor substance isolated from the culture supernatant of …

Endothelin (ET) is a potent vasoconstrictive peptide initially found in the conditioned medium
of cultured endothelial cells (1). It comprises 21 amino acid residues including four cysteine …

Endothelins (ET-1, ET-2 and ET-3) are a family of 21 amino acid peptides produced by
endothelial cells. They are thought to regulate the local vasomotor tone with endothelium …

Endothelin (ET) is a novel family of three isopeptides (ET-1, ET-2, ET-3) each containing
twenty-one amino acids and two disulfide bonds. Initially isolated from the supernatant of …

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Endothelin-1 (ET-1), a newly discovered peptide with potent vasoconstrictor and growth-
promoting effects, has been implicated in high blood pressure and cardiac hypertrophy in …

Circulating levels of endothelin-1 (ET-1) are elevated in a number of pathophysiological
conditions. Our aim was to determine the effect of overexpression of the peptide on ET …

Endothelin (ET)-1, an endothelium-derived peptide, is the most potent vasoconstrictor agent
described to date. ET-1 also has positive inotropic and chronotropic effects in the heart and …

Previous studies have characterized the endothelin peptides (ET-1, ET-2, ET-3) as strong
vasoconstrictors which are possibly involved in the pathogenesis of cardiovascular disease …

One year after the discovery in 1980 that the endothelium was obligatory for acetylcholine to
relax isolated arteries, it was clearly shown that the endothelium could also promote …