Abstract Endothelin (ET)-like immunoreactivity (-LI) was detected in the human
cardiopulmonary system, with the highest levels being found in the left anterior descending …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The ETs (endothelins) comprise a family of three 21-amino-acid peptides (ET-1, ET-2 and
ET-3) and 31-amino-acid ETs (ET-11–31, ET-21–31 and ET-31–31). ET-1 is synthesized …

Abstract Endothelin-1 (ET-1) is synthesized, stored and released in the human heart. On
release, ET-1 has the potential to activate specific receptors in a paracrine manner to modify …

Endothelin was isolated and identified in 1988 by Yanagisawa et al. The endothelin family
consists of 21 amino acid isoforms endothelin-1, endothelin-2 and endothelin-3. Endothelin …

Since its identification as an endothelial cell-derived vasoconstrictor peptide in 1988,
endothelin-1, the predominant member of the endothelin peptide family, has received …

The potent vascular, cardiac, and renal actions of endothelin-1 (ET-1) suggest a role for this
vasoconstrictor peptide in the pathophysiology of heart failure (HF). Recent studies have …

Endothelin (ET)‐1 is an endothelium‐derived peptide with potent vasoconstrictor and
proliferative properties. The ET system is activated in several cardiovascular disease states …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

Endothelin-1 (ET-1) is a recently discovered 21 amino acid peptide with potent
vasoconstrictor properties. So far, its expression has been found only in porcine aorta …