The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …

The normal functional state of the vasculature and the events leading to the development of
significant arterial disease involve the interaction of important vasoactive substances, which …

Endothelin-1 (ET-1) is a recently discovered 21 amino acid peptide with potent
vasoconstrictor properties. So far, its expression has been found only in porcine aorta …

Endothelins are ubiquitously produced 21-amino-acid peptides that were discovered as an
endothelial product and may play important roles in cardiovascular physiology and …

Endothelin-1, the most potent endothelium-derived vasoconstrictor peptide identified so far,
exerts multiple biologic effects that are potentially relevant for the pathogenesis of coronary …

The endothelin peptide family consists of the 21 amino acid isoforms endothelin-1,
endothelin-2, endothelin-3, and sarafotoxin (a snake venom). Endothelin-1 has been …

One year after the revelation by Dr. Furchgott in 1980 that the endothelium was obligatory for
acetylcholine to relax isolated arteries, it was clearly shown that the endothelium could also …

Endothelin (ET) is a potent vasoconstrictive peptide that was isolated initially from the
conditioned medium of cultured endothelial cells. In 1988, details of the isolation and …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Abstract Endothelin (ET)-1, a 21-amino acid peptide, is the predominant isoform of the
endothelin peptide family. ET-1 is ubiquitously expressed and stimulates vasoconstriction …