Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection …
Genome-wide association studies have identified multiple risk variants and loci that show
robust association with schizophrenia. Nevertheless, it remains unclear how these variants …
robust association with schizophrenia. Nevertheless, it remains unclear how these variants …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia
J Liu, S Li, X Li, W Li, Y Yang, S Guo, L Lv, X Xiao… - BMC medicine, 2021 - Springer
Background Over 200 schizophrenia risk loci have been identified by genome-wide
association studies (GWASs). However, the majority of risk loci were identified in …
association studies (GWASs). However, the majority of risk loci were identified in …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
CP Yang, X Li, Y Wu, Q Shen, Y Zeng, Q Xiong… - Nature …, 2018 - nature.com
Recent genome-wide association studies (GWAS) have identified multiple risk loci that show
strong associations with schizophrenia. However, pinpointing the potential causal genes at …
strong associations with schizophrenia. However, pinpointing the potential causal genes at …
RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia
Background While genome-wide association studies identified some promising candidates
for schizophrenia, the majority of risk genes remained unknown. We were interested in …
for schizophrenia, the majority of risk genes remained unknown. We were interested in …
The integrated landscape of causal genes and pathways in schizophrenia
C Ma, C Gu, Y Huo, X Li, XJ Luo - Translational psychiatry, 2018 - nature.com
Genome-wide association studies (GWAS) have identified more than 100 loci that show
robust association with schizophrenia risk. However, due to the complexity of linkage …
robust association with schizophrenia risk. However, due to the complexity of linkage …
Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay
R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
Integrated post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-
wide association studies (GWAS) have identified many schizophrenia-associated common …
wide association studies (GWAS) have identified many schizophrenia-associated common …